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  • Lundbeck’s bexicaserin receives Breakthrough Therapy Designation in China for the treatment of seizures in severe rare epilepsies

    • Accelerated pathway underscores urgent need for innovative solutions for patients with devastating, childhood-onset epilepsies
    • Novel 5HT2C mechanism designed to reduce drug-resistant seizures in children and adults living with Developmental Epileptic Encephalopathies (DEEs) and improve quality of life for patients and their caregivers1
    • Dual Breakthrough Therapy Designation (BTD) in China and the U.S. underscores Lundbeck’s mission to advance brain health and transform lives of patients with rare neurological diseases

    VALBY, Denmark, Oct. 13, 2025 /PRNewswire/ — Lundbeck today announced that its investigational drug bexicaserin, for the treatment of seizures associated with Developmental and Epileptic Encephalopathies (DEEs), has been granted Breakthrough Therapy Designation (BTD) by China’s Center for Drug Evaluation (CDE).

    DEEs are a heterogeneous group of severe, childhood-onset, rare epilepsies marked by drug-resistant seizures and developmental stagnation or regression.2 Affecting more than 1 in 2,000 live births, DEEs carry a mortality rate of 17–50%.3 Survivors are often left with profound neurological disabilities, creating a heavy burden for families and society and underscoring the urgent need for new treatment options.4

    “We are honored that bexicaserin has been granted Breakthrough Therapy Designation, recognizing the potential of our innovative approach to advancing treatment in one of the most challenging areas of epilepsy,” said Johan Luthman, EVP and Head of Research & Development at Lundbeck. “Drawing on our expertise in neuroscience, and past experiences with epilepsy therapies, we are deeply committed driving the global Phase 3 clinical program forward. Obtaining BTD for the program in China supports us in bringing Bexicaserin to patients living with DEEs as quickly as possible.”

    Bexicaserin (LP352) is a novel investigational, oral therapy that selectively targets the 5-HT2C receptor while avoiding activity at the 5-HT2B and 5-HT2A subtypes, a profile designed to reduce cardiovascular risk. The medicine has also been granted BTD by the U.S. Food and Drug Administration (FDA) for the treatment of seizures associated with DEEs.

    “Bexicaserin’s Breakthrough Therapy Designation is an important step forward for Lundbeck in China and reflects our dedication to addressing the urgent needs of patients living with DEEs,” said Zhang Yifan, Managing Director of Lundbeck China. “This recognition strengthens our commitment to bringing innovative neuroscience solutions to China, working hand in hand with partners to advance brain health and improve the lives of patients and their families.”

    The BTD procedure is designed to accelerate the development and review of innovative medicines for serious or life-threatening diseases with no adequate treatment options, or where early evidence shows substantial advantages over existing therapies. The CDE prioritizes resource allocation, communication, enhanced guidance, and development promotion for drugs included in the BTD drug procedure.

    About Bexicaserin
    Bexicaserin (LP352) is an oral, centrally acting 5-hydroxytryptamine 2C (5-HT2C) receptor agonist with no engagement of the 5-HT2B and 5-HT2A receptor subtypes, potentially minimizing the risks of cardiovascular toxicity.1 Bexicaserin is being evaluated in a global Phase 3 clinical program (the DEEp Program). The FDA has granted Breakthrough Therapy designation for bexicaserin for the treatment of seizures associated with Developmental and Epileptic Encephalopathies (DEEs) for patients two years of age and older.5 Bexicaserin is an investigational compound that is not approved for marketing by any regulatory authority worldwide. The efficacy and safety of bexicaserin has not been established.

    About DEEs
    Developmental and Epileptic Encephalopathies (DEEs) are a group of rare neurodevelopmental disorders that typically manifest in early childhood. These heterogeneous and severe epilepsy syndromes are characterized by refractory seizures and developmental stagnation or regression. According to the International League Against Epilepsy (ILAE), DEEs currently encompass more than 10 syndromes, including Early Infantile DEE (EIDEE), Infantile Epileptic Spams Syndrome (IESS), Dravet Syndrome, and Lennox-Gastaut Syndrome with various etiologies among those mainly genetic (e.g., CDKL5, STXBP1, KCNT1, SCN2A). Some of these conditions have been included in the first and second batches of the Rare Disease Catalog released by the National Health Commission.

    Contacts
    Anders Crillesen 
    Head of Media Relations, Corp. Communication
    [email protected]
    +45 27 79 12 86

    Jens Høyer
    Vice President, Head of Investor Relations 
    [email protected] 
    +45 30 83 45 01

    About H. Lundbeck A/S
    Lundbeck is a biopharmaceutical company focusing exclusively on brain health. With more than 70 years of experience in neuroscience, we are committed to improving the lives of people with neurological and psychiatric diseases.

    Brain disorders affect a large part of the world’s population, and the effects are felt throughout society. With the rapidly improving understanding of the biology of the brain, we hold ourselves accountable for advancing brain health by curiously exploring new opportunities for treatments.

    As a focused innovator, we strive for our research and development programs to tackle some of the most complex neurological challenges. We develop transformative medicines targeting people for whom there are few or no treatments available, expanding into neuro-specialty and neuro-rare from our strong legacy within psychiatry and neurology.

    We are committed to fighting stigma and we act to improve health equity. We strive to create long term value for our shareholders by making a positive contribution to patients, their families and society as a whole.

    Lundbeck has approximately 5,700 employees in more than 50 countries and our products are available in more than 80 countries. For additional information, we encourage you to visit our corporate site www.lundbeck.com and connect with us via LinkedIn.

    References:

    1. Ren A, et al. J Medicinal Chem. 2025;68(11):10599-10618
    2. Scheffer IE, et al. Epilepsia. 2025;00:1-10
    3. Palmer EE, et al. Neurotherapeutics. 2021;18(3):1432–1444
    4. Gallop K, et al. Epilepsy Behav. 2021;124:10824
    5. Longboard Pharmaceuticals News Release 2024. Longboard Pharmaceuticals Receives Rare Pediatric Disease Designation and Orphan Drug Designation for Bexicaserin (LP352) in Dravet Syndrome

    CONTACT:
    H. Lundbeck A/S
    Ottiliavej 9, 2500 Valby, Denmark
    +45 3630 1311
    [email protected]

    This information was brought to you by Cision http://news.cision.com

    https://news.cision.com/h–lundbeck-a-s/r/lundbeck-s-bexicaserin-receives-breakthrough-therapy-designation-in-china-for-the-treatment-of-seizu,c4248555

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  • HSR 3.7 Update Leaks New Skins Coming for Cyrene and Remembrance Trailblazer

    HSR 3.7 Update Leaks New Skins Coming for Cyrene and Remembrance Trailblazer

    Cyrene is set to become playable in Honkai Star Rail 3.7, closing off the Amphoreus cycle in style. Being and Elysia EXPY, she is among the most anticipated characters in Star Rail, and Hoyoverse plans to take full advantage of that. A…

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  • Seasonal Patterns and Subtype Distribution of Influenza Viruses in a Tertiary Care Hospital in North India: A One-Year Observational Study

    Seasonal Patterns and Subtype Distribution of Influenza Viruses in a Tertiary Care Hospital in North India: A One-Year Observational Study

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  •  MTN at MWC Kigali 2025 |

     MTN at MWC Kigali 2025 |

    MTN is proud to once again be part of MWC Kigali, Africa’s leading technology event, taking place from 21 – 23 October 2025 at the Kigali Convention Centre, Rwanda. Hosted by the GSMA, the gathering brings together government, industry and technology leaders to explore how digital innovation can unlock inclusive growth across the continent.

    For MTN, MWC Kigali is an opportunity to showcase progress across our networks, fintech, digital services and skills initiatives, while engaging with policymakers and partners to secure an inclusive and sustainable digital future for Africa.

    Advancing Africa’s Digital Agenda

    As a founding partner of MWC Africa, MTN continues to value the platform’s role in listening, learning and sharing ideas to accelerate Africa’s digital transformation.

    This year, our participation will be headlined by Ralph Mupita in Keynote 1: Africa’s Future First – Determining the Path to a Digital Future. The session will explore Africa’s digital transformation journey, with unique mobile subscribers projected to surpass 700 million by 2030, and examine how technologies such as AI, fintech, 5G and green innovation are reshaping industries and driving inclusive growth.

    Beyond the keynote, MTN leaders will join panels and roundtables on infrastructure investment, FinTech, AI adoption, online safety, and Africa’s connected future.

    An Immersive MTN Stand

    Visitors to the MTN stand will experience how our platforms and innovations translate into real value for Africa’s digital future.

    Together, these platforms highlight MTN’s commitment to equipping Africa for the digital economy and creating pathways to employment and innovation.

    In collaboration with Ericsson, MTN will also showcase 5G-enabled applications that demonstrate the impact of real-time connectivity:

    • HADO – an augmented reality game debuting in Africa, showing how low latency supports interactive learning, health and skills training
    • 5G-enabled robotic dog – illustrating how connected tech enhances safety and efficiency in mining, utilities and energy
    • Ray-Ban Display smart glasses – featuring neural gesture control for future possibilities in accessibility, workforce productivity and digital interactions

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  • Free screening of The Promise documentary brings mental health stories to Maitland

    To mark Mental Health Month this October, Maitland City Council will host a free community screening of the documentary The Promise on Thursday 30 October from 6pm at Reading Cinemas, Maitland. 

    The screening will be followed by a panel…

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  • World’s First 20,000mAh, 67W Fast-Charging Power Bank with Integrated 4G Hotspot Connectivity

    World’s First 20,000mAh, 67W Fast-Charging Power Bank with Integrated 4G Hotspot Connectivity

    SHENZHEN, China, Oct. 13, 2025 /PRNewswire/ — Baseus, a global leader in consumer electronics, unveils the EnerGeek GX11 4G MiFi Power Bank, the world’s first 20,000mAh, 67W fast-charging power bank with integrated 4G…

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  • Men’s Tennis Wraps Up Weekend Play at Intercollegiate Championships & UC Davis Invitational

    Men’s Tennis Wraps Up Weekend Play at Intercollegiate Championships & UC Davis Invitational

    SAN DIEGO Valentin Faure’s run at the Intercollegiate Championships came to an end in the semifinals, falling

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  • NFL results & week six review: Buccaneers & Colts go 5-1, season over for Ravens?

    NFL results & week six review: Buccaneers & Colts go 5-1, season over for Ravens?

    Image source, Getty Images
    Image caption,

    Could Baker Mayfield (left) be the MVP? The Buccaneers fans think so

    With a third of the NFL season gone teams are starting to show their true colours, with some surprising…

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  • The next generation of travel in Asia: Trust, experience and the coming AI wave

    The next generation of travel in Asia: Trust, experience and the coming AI wave

    At the Next Generation Leaders event on October 9, held as part of WiT Singapore, four voices from across Asia’s travel ecosystem—Laura Houldsworth (Booking.com), Timothy Hughes (Agoda), Morris Sim (Montara Hospitality) and Jacinta Lim (Seek Sophie)—examined how the new travel landscape is being reshaped by artificial intelligence (AI), authenticity and the fight for trust.

    The age of acceleration

    Houldsworth set the tone: “The pace of change is dizzying. It’s not just planning for what happens next year, but what happens tomorrow.”

    The event, sponsored by Booking.com and open by-invite to about 60 young leaders from across Asia’s online travel market, opened on how fast AI is shifting the travel equation. OpenAI, Houldsworth noted, now counts over 800 million active weekly users, a four-fold jump in less than a year.

    “Except for when Taylor Swift announces something,” Houldsworth said. “I can’t think of anything that happens faster.”

    But the challenge, she said, goes beyond scale, with people now searching for vibe. “How does it feel? What’s the vibe, the experience? That’s hard to put into a booking engine, that’s what will change the game.”

    The funnel, unbroken but redrawn

    Hughes of Agoda offered a note of grounding. “As much as technology changes, the fundamental funnel doesn’t. Someone still needs to be inspired—that’s unbreakable. What changes is who wins in each part of it.”

    He recalled that in the pre-AI era, content was the loser. “Search belonged to Google. Bookings went to the OTAs. But now, with AI shifting the power of the funnel, the content question is back.”

    Already, Google Gemini and OpenAI are capturing search intent in new ways. One percent of searches may not sound like much, but when you’re talking about billions, it’s enormous, the panel acknowledged.

    The boardroom moment for AI

    At Montara Hospitality, AI has become a standing agenda item. “Every board meeting now includes an AI update,” said Sim. “Our operations managers are all trained in it.”

    Distribution used to mean choosing your channels. Now, you’re expected to be in all of them and AI helps you manage that chaos.

    Morris Sim, Montara Hospitality

    For him, the question isn’t whether to use it, but how. “Distribution used to mean choosing your channels. Now, you’re expected to be in all of them and AI helps you manage that chaos.”

    Yet, he added, the key is still emotion. “How do you communicate the vibe of a place? Ironically, what we put out ourselves gets the least traction. What guests create, that’s what people consume and influence.”

    Trust in an age of skepticism

    That trust deficit—across media, marketing and institutions—was a recurring theme. “People are skeptical. They look for multiple sources and construct their own truth,” Sim said. “AI, used well, can help aggregate those voices and even translate them into different languages.”

    He recounted instances of guests saying, “ChatGPT proposed this itinerary—why isn’t it in yours?”

    “It keeps us on our toes,” he said. “We have to be service-oriented but flexible. It’s less about talking about our products—we have a spa, we have a gym—but more about understanding what questions people are asking, what prompts they are using.”

    The human pulse of discovery

    For Lim, co-founder of Seek Sophie, the drive for experiences and authenticity hasn’t changed—only how people find it. “We started Seek Sophie because we couldn’t find the experiences we wanted online. Even on page 10 of Google, it was the same lists, same SEO.”

    Her insight is clear: “People want stories, from people who’ve actually been there. They want the vibe, not a chatbot summary.”

    Her comment drew nods around the room. “The more stories we tell, the more people resonate. That’s how trust builds, through voices that sound like theirs.”

    Social media, she added, has become “the new luxury.”

    “It’s telling people you’ve been to this place; it’s about relatability. The new aspiration is to live a story worth telling.”

    Asia’s responsibility to its future

    On tourism’s responsibility to the environment, Hughes shared his frustration with an airline he flew with from Bangkok to Singapore that was still giving away plastic shoehorns to its business class passengers as well as socks and eye masks on short flights. “That’s completely unnecessary.”

    Quote

    As we look at the protests going on in Europe, we in Asia have to be very careful. Our livelihoods depend on tourism assets, and we don’t have the muscle to protect these natural places.

    Jacinta Lim, Seek Sophie

    Lim also issued a quiet warning. “As we look at the protests going on in Europe, we in Asia have to be very careful. Our livelihoods depend on tourism assets, and we don’t have the muscle to protect these natural places. As Asia booms, what does tourism do to our natural spaces and how do we protect them?”

    Responding to a question as to whether Seek Sophie could become bigger than Viator, Lim said, “If that’s the responsible thing to do, to be bigger, then yes. But growth at all costs, I don’t agree with that.”

    An industry at a crossroads

    Hughes brought the conversation full circle. “Sure, tech will change—AI, content, speed of development. But what we don’t yet know is how consumers will change. That’s the real unknown.”

    He likened this moment to “the beginning of a monster change.”

    Houldsworth added, “Even the people building the tools don’t know where this goes. All we can do is stay agile.”

    The Asian moment

    For Sim, this decade belongs to Asia. “Asia is shaping the global narrative now. You see Europeans, Australians, Americans coming here not just for holidays but to explore why our countries are so interesting.”

    Between Japan’s inbound boom and South-east Asia’s economic rise, he said, “There’s an endless amount of opportunity in the next 50 years—as more people enter the middle class and start travelling for meaning, not mileage.”

    This article originally appeared in WiT.

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  • On Test | The fourth generation Norco Sight VLT CX is a Bosch powered high-pivot e-MTB

    On Test | The fourth generation Norco Sight VLT CX is a Bosch powered high-pivot e-MTB

    Norco launched the new Sight VLT CX in late 2024, and it left a few folks scratching their heads, and Norco has already launched updated Sight and Range VLTs that year. The launch actually coincided with the debut of the new Bosch…

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